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Despite a plethora of studies examining the effects of GSNO both in vitro and in vivo , few studies have identified the compound which actually S-nitrosates a specific protein thiol, whether it be GSNO or another GSNO-derived low molecular weight S-nitrosothiol (e.g., L-CysNO)

10.1016/j.aca.2022.340307 31 DuboisF.KellerM.CalvayracO.SoncinF.HoaL.HergovichA.et al (2016)

introduced polysorbate 80-modified chitosan nanoparticles into the rat brain, and after a period of time, found that the rat brain cells died[192]