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There may be some amount of discomfort during the administration which is usually tolerable

Exopolysaccharides of lactic acid bacteria for food and colon health applications

561 At the end of 1 year, DEXA measurements of BMD had improved slightly in the low-prednisone group versus the high-prednisone group, and the inter-group difference was statistically significant (d = 1.409, 95% CI, 0.92 to 1.02, Hedges d test for standard effect sizes)

Multivariate and univariate analyses were performed in a MATLAB environment in order to identify APAP metabolites after APAP, APAP-Cys, NAC-APAP, and APAP-SG exposures as described in the supplementary information