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253 In senescent cells, mitochondrial proton leak was observed, associated with the weakened proton gradient and further reducing the efficiency of ATP synthesis

doi: 10.1007/s10517-016-3167-y

Crucially, synergistic interplay between these modalities, such as combining senolytics with epigenetic reprogramming or mTOR inhibition, should be rigorously explored to increase efficacy while minimizing unintended adverse effects

Hijaz and Killiny, 2019)

Anemia of Chronic Disease There can be changes in the red blood cells and their oxygen-carrying capacity in people with chronic diseases such as chronic kidney disease