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Results vary by dose, route, baseline pigmentation, and cofactors like vitamin C

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This forms a pathogenic positive feedback looplinking iron accumulation, A/tau pathology, and ferroptosiswhich collectively exacerbate neuronal injury (Yadav et al., 2023

These findings suggest that a GST tag is not an authentic TG2 substrate but instead is accidentally crosslinked by TG2 during cell lysate incubation

This improvement may enhance neurotransmitter production, release, and storage, reducing degenerative brain lesions