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These effects cannot be solely explained by different drug potencies, metabolites and pharmacokinetic properties

10.2174/1381612821666150710144502 [DOI] [PubMed] [Google Scholar] 40.Pellerin L, Magistretti PJ

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In a study of fluoride-induced apoptosis in follicular granulosa cells, results showed that mitochondria in granulosa cells exhibited typical features of ferroptosis, such as reduced mitochondrial volume and reduced mitochondrial crags [51]

These events not only damage the cell and plasma membranes but also induce the formation of protein pores in the cell membrane, disrupting intracellular homeostasis [185, 186]