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Grant, D.M

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

Nonetheless, although aging is associated with increased systemic inflammation, comparisons to prior studies on the effect of aging on the plasma/whole-blood metabolome in humans (74, 75) and animal models (52, 54, 56) does not suggest that the observations reported here are due to aging alone

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