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They administered a single dose of NMN (500 mg/kg i.p.) and found that NMN could prevent islet dysfunction in the model mice

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors Proc Natl Acad Sci USA 1994 91 : 43484352 Mullen CA, Coale MM, Lowe R, Blaese RM