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Though IV and oral NAC loading doses were similar (140-150 mg/kg), the oral NAC regimen provided an additional 70 mg/kg every 4 hours for 17 doses, while the IV NAC regimen provided an additional 12.5 mg/kg/h for 4 hours, followed by 6.25 mg/kg/hr for the next 16 hours

However, previous studies suggest that processes occurring during I/R, such as the release of ROS leading to lipid peroxidation (70) and the accumulation of intracellular iron (71), are closely linked to ferroptosis

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Furthermore, the decrease of the dopaminergic action on neurons with striatal D1 receptors leads to an attenuation of the GABAergic inhibitory action of the striatal neurons on the GPi

For these individuals, a conservative schedule extends each dose step to 6 weeks instead of 4, giving the body additional adaptation time