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The most important ROS include several small chemical compounds such as the superoxide anion, hydroxyl anion (OH ), hydrogen peroxide (H 2 O 2 ), nitric oxide (NO), and peroxynitrite (ONOO ) (Suvorava and Kojda, 2009)

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Those are paired with a soothing lineup of Centella asiatica , madecassoside, panthenol, and allantoin to keep skin balanced (as irritation can worsen pigmentation)

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As mitochondrial-targeted strategies advance toward clinical application, functional biomarkers of mitochondrial activity are emerging as important tools for predicting treatment response