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This effect can affect the utilization of food proteins and digestive enzymes, which may lead to impaired function and disturbances during biochemical reactions or processes that a given enzyme catalyzes

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These studies demonstrate that strategies such as improving tumor vessel function, reducing interstitial pressure, and regulating collagen cross-linking can effectively enhance the distribution of immunotherapeutic drugs in tumor tissues and T cell infiltration, thereby improving the efficacy of immunotherapy

In addition, bile acids shape the composition of the gut microbiota and are transformed by gut bacteria, creating a feedback mechanism essential for liver and gut health (48)

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