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doi: 10.1186/s12931-025-03113-z 90 XieSZhangCZhaoJLiDChenJ

Tolerance is expected to occur when a drug effect is decreased after repeated administrations or the need to increase a substance or medication dose to obtain the same effect

10.1006/bbrc.1997.6921 318 VictorV

Women of reproductive age are particularly susceptible, especially during pregnancy, which is why it is often called the mask of pregnancy. Individuals with medium to dark skin tones, including many South Asians, including Bangladeshi people, have a higher risk because their skin naturally produces more melanin