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Identification of activated cell signaling pathways in VEGFR2-Fcexpressing tumors To identify activated cell signaling pathways in tumors after chronic exposure to VEGFR2-Fc, RNA-Seq analysis was performed by using Mock and VEGFR2-Fc expressing tumors

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Therefore, a meta-defencor targeting mitochondria has been developed, which scavenges mtROS and suppresses mitochondrial nitric oxide synthase, thereby increasing mitochondrial transcription factor A expression, restoring aerobic respiration, and reprogramming mitochondrial metabolism for the conversion of M1 macrophages to M2 macrophages (135)