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Targeting Axon Integrity to Prevent Chemotherapy-Induced Peripheral Neuropathy

Rights and permissions About this article Cite this article Trevaskis, N., Kaminskas, L

Sample-level quality control also included visual inspection of quality control plots, hierarchical clustering, and principal component analysis (PCA) to identify potential outliers

N-acetylcysteine (NAC) pretreatment abolished PPVII-mediated cytotoxicity, autophagic flux, and AKT/mTORC1 suppression, establishing ROS overproduction as the central mechanistic driver of these phenomena