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In addition to Keap1-mediated ubiquitination and degradation, NRF2 stability is regulated by other mechanisms

Kojima M, Ogiya D, Ichiki A, Hara R, Amaki J, Kawai H, et al

Moreover, SLNs address limitations of Rif, such as solubility and absorption, by enhancing its stability and permeability in intracellular environments [153]

Approximately 8085% of absorbed iron is transported by transferrin to the reticuloendothelial system or to bone marrow for incorporation into hemoglobin, stored in the liver or muscle, or used for heme synthesis [2]

Experiments in cells show that the association-induced folding of the intrinsically disordered C H 1 domain is a limiting factor for the ER exit of the SLC and SLC-HC complexes