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We tested the above hypothesis first in the reduced model and then in the full Reed-Nijhout model (For details please see Data Sheet 1)

Additional studies have highlighted the involvement of both Bax and caspase 3 in PD neurodegeneration across various models, including SH-SY5Y cells (Itano and Nomura, 1995), PC12 cells (Blum et al., 1997), human post-mortem tissue (Tatton, 2000) and mice (Yamada et al., 2010)