inhibition of influenza infection by glutathione Frontiers Redox control in the pathophysiology

Nature, 472: 476480

The liver protects itself from harmful oxidative reactions by producing glutathione inside its cells

The evidence does not convincingly demonstrate superiority of SAG over standard glutathione

Here, we leveraged human genetic data, dysmetabolic rodent models, humanized experimental models, toxicology studies and a phase 1 clinical trial to evaluate the tolerability and efficacy of TLC-2716, an orally administered LXR inverse agonist, which to date has not been tested in humans 19,29

Given the inextricable link between immune system dysregulation and organismal aging, future research on preventing or mitigating immunosenescence may prioritize the integrated application of the therapeutic strategies discussed herein