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This disruption affects the inhibitory regulation between neurons, thereby disrupting the excitation/inhibition balance in the brain and promoting the emergence of core symptoms of ASD ( Futhermore, the aristaless-related homeobox (Arx) transcription factor, located on the X chromosome, has been implicated in a wide range of neurological disorders, including intellectual disability and epilepsy, as well as ASD

Negative controls were obtained by running PCR with H 2 O instead of the template

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Although nanotechnology-based delivery systems have been explored to address these challenges, the current literature lacks mechanistic integration and critical comparison of nanoformulation strategies

doi: 10.3390/ijms22094912 90 PoeweW.SeppiK.TannerC