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Alongside this perspective, another view is that ROS is produced endogenously or in response to treatment, that also triggers p53 [67], but the link describing cisplatin treatment and its metabolic disruption was not established

PMid:12743340 PMCid:PMC1742688 Butler CC, Vidal-Alaball J, Cannings-John R, et al

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18 , 227 230 Although the quality and amount of data varies considerably between diseases, increased in growth factor quantities were generally associated with increased acute damage signals and monocyte and neutrophil chemokines in these patients