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( Epub 2020 Oct 6 )

Dysregulated lipid metabolism is involved in various diseases, including acute and chronic inflammatory disorders and cancers

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Its downregulation has been shown to suppress the degradation of unsaturated fatty acids through multiple mechanisms, including inhibiting the activity of key enzymes involved in fatty acid catabolism (e.g., acetyl-CoA dehydrogenase, lipoxygenase, and fatty acid dioxygenase) and activating the PPAR signaling pathway and its downstream target genes [71]

This disorder is associated with other chronic diseases, such as hypertension, stroke, depression, anxiety, and cardiovascular diseases (2, 5, 6)