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doi: 10.1016/j.semcancer.2005.07.004 57 PereiraMDursoDFBryantCEKurt-JonesEASilvermanNGolenbockDTet al

It is the main consumer of NAD + in aged tissues its activity increases significantly after age 40

NAD-MDH usually exists in the cytoplasm and mitochondria of bacteria and eukaryotic cells

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