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Description

In further embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, and 2aa

Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, Biswal S

10.1021/acsbiomaterials.2c01006

doi: 10.1089/ars.2019.7803 24

Intracellular cysteine can be synthesized from methionine by the transsulfuration pathway (Figure 1) and not only by the reduction of imported cystine