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An update on the pharmacological usage of curcumin: has it failed in the drug discovery pipeline

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Glossary NF-B Nuclear factor kappa-B NLRP3 NOD-like receptor thermal protein domain associated protein 3 Nrf2 Nuclear Factor Erythroid 2-related Factor 2 TGF- Transforming growth factor IL-10 Interleukin 10 CNS Central nervous system TNF- Tumor necrosis factor- IL-1 Interleukin-1 IL-6 Interleukin- 6 ROS Reactive oxygen species AD Alzheimers disease PD Parkinsons disease MS Multiple sclerosis TLRs Toll-like receptors BBB Blood-brain barrier NSAIDs Non-steroidal anti-inflammatory drugs MAPK Mitogen-Activated Protein Kinase PI3K/Akt Phosphatidylinositol 3-Kinase/Akt HAT Hydrogen atom transfer SET Single electron transfer STAT3 Signal transducer and activator of transcription 3 LPS Lipopolysaccharide NO Nitric oxide HO-1 Heme Oxygenase-1 TBI Traumatic brain injury SAH Subarachnoid hemorrhage TREM2 Triggering receptor expressed on myeloid cells 2 EAE Experimental autoimmune encephalomyelitis A Amyloid- AChEIs Acetylcholinesterase inhibitors DG Dentate gyrus T2D Type 2 diabetes GBE Ginkgo biloba extract P-tau Phosphorylated tau MDA Malondialdehyde GSH Glutathione CNPs Curcumin nanoparticles SNCA -synuclein LRRK2 Leucine-rich repeat kinase 2 MHC Major histocompatibility complex CPZ Cuprizone IFN- Interferon- HPPS High-density lipoprotein-mimicking peptide-phospholipid scaffold PNC Polymeric forms of nano-curcumin hUC-MSC Human umbilical cord-derived mesenchymal stem cells ALS Amyotrophic lateral sclerosis SLCP Solid lipid curcumin particles FUS Fused in sarcoma SOD1 Superoxide dismutase 1 PTZ Pentylenetetrazol PET Positron emission tomography NDs Neurodegenerative diseases HD Huntingtons disease DAMPs Damage-associated molecular patterns NPs Nanoparticles SLNs Solid lipid nanoparticles References 1 AbdollahiE.JohnstonT

MicroRNA expression profiling analysis in serum for nasopharyngeal carcinoma diagnosis