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R-Lipoic acid impairs PDK binding and phosphorylation efficiency toward PDHC [185], whereas its analog CPI-613 disrupts mitochondrial metabolism by targeting PDHC and -ketoglutarate dehydrogenase/2-oxoglutarate dehydrogenase (OGDH), achieving tumor-selective cytotoxicity [186, 187]

Intrinsic factor is a stomach protein that helps the body absorb B12

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It has been hypothesized that IGF-1 LR3 may support neuronal survival and synaptic plasticity through its interaction with IGF-1R in the central nervous system

Early myelination during CNS development can be observed in the hindbrain and midbrain at 3 month and postnatal day 7 (P7) in human and rat, respectively