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139 Sirtuins are an additional class of NAD + -dependent HDACs whose activity is indirectly redox-regulated through their dependence on the NAD + /NADH ratio maintained by the TCA cycle and affected by mitochondrial ROS production

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Although a meta-analysis from 2017 suggested beneficial effects [16], a recent large RCT found no significant benefits of adjunctive continuation of escitalopram or bupropion XL for 52 weeks compared with treatment for eight weeks in terms of preventing relapse of any mood episode [17]

10.1038/nrdp.2017.40 25 HigginsJ.GreenS

Nutrients 9, 1021