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46 Laboratory findings The laboratory abnormalities found in DJS include elevation of conjugated and total bilirubin in the serum but normal aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and -glutamyltransferase (GGT) levels

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However, it is not possible to selectively inhibit DYRK1A expression

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doi: 10.3389/fimmu.2025.1633406 Received 22 May 2025 Accepted 30 July 2025 Published 18 August 2025 Volume 16 - 2025 Edited by Allen Jay Rosenspire, Wayne State University, United States Reviewed by Jun Deng, Shanghai Jiao Tong University, China David Lawrence, New York State Department of Health, United States Updates Copyright 2025 Zheng, Zhai, Wang and Pan

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Microglia metabolism in health and disease

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The threshold Glide XP score and MMGBSA binding affinity values were set at -8 and -60 Kcal/mol respectively (based on docking scores with the substrate, glutathione) for the final screening of compounds

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