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1 - Treatments to Address Curvature, Indentation or Penile Atrophy The following treatments can be employed to soften or minimize the fibrotic plaque that develops with Peyronies: Oral Medications Pentoxifylline - Pentoxifylline is a nonspecific phosphodiesterase inhibitor which decreases transforming growth factor (TGF) beta-1-mediated fibrosis, prevents deposition of collagen type I, and reduces calcification

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Cerebral pharmacokinetics and microdialysis To confirm that a peptide actually reaches its cerebral target, microdialysis remains the reference tool: Principle : insertion of a semi-permeable membrane probe in a target region (hippocampus, frontal cortex)

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