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While studies suggest that B-vitamin therapy, including B12, may reduce stroke risk, particularly ischemic and subarachnoid hemorrhages, clinical trial results remain inconsistent, warranting further research into its cardiovascular benefits (7)

Pregnancy, placental biology, and implantation Endogenous HCG and its hyperglycosylated variants regulate implantation, trophoblast invasion, angiogenesis, and placental development, so they are widely studied in preeclampsia, recurrent pregnancy loss, and gestational trophoblastic disease

rare variants cause energy deficiency SLC52A3 and SLC52A2 riboflavin transporters

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