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In pancreatic cells, activation of these G proteincoupled receptors is primarily mediated through pathways involving cyclic adenosine monophosphate (cAMP), protein kinase A ( PKA ), and cAMP response elementbinding protein ( CREB ), thereby enhancing glucose-dependent insulin secretion and supporting -cell function

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doi: 10.1016/j.bcp.2023.115522 177 MorassoC.TruffiM.TinelliV.StivaktakisP.Di GerlandoR.FrancescaD.et al

Rat research and older clinical reports exist, but no modern confirmatory trial establishes Epithalon as a retinal-disease treatment

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