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Reboldi, A

Further research is required to fully elucidate the interplay of NRF1 and NRF2 following GSH depletion in the liver

This approach could reduce unwanted side effects and enhance therapeutic efficacy (151, 152)

Further insights into catalase structure : As mentioned above, only LSCs from clade 2 possess the short tetrapeptide gate interrupting the main channel from the surface of catalase down to the enzymes active sites