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The ratio of GSH to GSSG is a key indicator of cellular oxidative stress, with a healthy cell maintaining a ratio greater than 100:1 [2][5]

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The major arsenic compounds detected in the earthworms were arsenous acid and arsenic acid

However, NAC increases intracellular level and bioavailability of Glutathione

While the haem biosynthesis and degradation pathway has already been demonstrated to be synthetic lethal in FH-deficient cells, the role of GSH metabolism in FH-deficient cells has not been investigated before and required further investigation