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L.CordatE.KajimuraM.LeipzigerJ

The cells were differentiated with PC-conditioned medium and cARLA (48 h) and the confluent monolayers were incubated with nanocarriers (100 g/ml) diluted in hEC culture medium at 37 C for 24 h in a CO 2 incubator

Since Fe(II) catalyzes the Fenton reaction to produce the free radical OH * from hydrogen peroxide, its upregulation presents a paradox: Nrf2 also boosts the expression of the genes encoding several components of the ferritin complex that detoxifies Fe(II) by converting it to Fe(III) and then stores it 22

There's also an initial adjustment period where detox signs can show, like changes in body odour, but those usually settle down