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At the epithelial interface, probiotic bacteria, including Bifidobacterium -containing formulations, can preserve tight junction organization (e.g., ZO-1/occludin/claudins) and counter increases in permeability, thereby limiting the translocation-driven inflammatory amplification that is central to radiation-induced mucosal injury 90

Hyaluronic acid (injection route) - Side effects & uses. Mayo Clinic Drug Information, 2024

appears to suggest that such a trade-off indeed exists for antimalarials, particularly with therapy targeting host factors

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