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Potential mechanisms include mitochondrial dysfunction, increased low-grade inflammation, lipid accumulation, and oxidative stress in intramuscular cells, as well as accumulation and decreased autophagy and enzyme activity in aging cells (Jiao and Demontis, 2017

Methyldopa is taken up into the presynaptic terminal, where it undergoes enzymatic conversion by aromatic Lamino acid (DOPA) decarboxylase to form methyldopamine ( panel 1 )