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Faster aging markers : After menopause, women lose estrogen protection - bone density drops faster, skin ages more rapidly, metabolic rate slows significantly

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CKD contributes to atherosclerosis not only by increasing traditional risk factors like hypertension (Valdivielso et al., 2019), dyslipidemia and inflammation, but also through CKD-specific alterations like albuminuria and the accumulation of uremic retention solutes (Vondenhoff et al., 2024)

Moreover, the expected inhibition of cellular proliferation is manifested as bone marrow suppression, and oral and gastrointestinal ulcers, and may require lowering the dose of the drug and, usually, the efficacy of the therapy, suggesting that inhibition of cellular proliferation alone is not responsible for the anti-inflammatory effects of methotrexate

[DOI] [PMC free article] [PubMed] [Google Scholar] 219.Li Y, et al