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When used responsibly and under medical supervision, they can be a powerful tool in promoting healing and enhancing physical capabilities

However, the foundational mechanism paper (Benoist et al., 2014 in J Pharmacol Exp Ther) establishing Dihexas HGF/c-Met pathway activation was formally retracted in April 2025 after being flagged since 2021

It includes 25P/28P/29P mutations to reduce the proteins propensity to form fibrils and -sheets and the insertion of a C-terminal proline improves binding to the CTR channel