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Torkamani et al., 2018

NAD+ and Glutathione depletion in chronic diseases NAD+ levels drop with age in many species, including humans

Med Hypotheses (2012) 78:54852.10.1016/j.mehy.2012.01.032 71 JamesSJCutlerPMelnykSJerniganSJanakLGaylorDWet alMetabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

It's not that CBD can't be used with these - many veterinarians successfully incorporate CBD into treatment plans - but dosages may need adjustment for both the CBD and the prescription medication