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This activation reduces HO levels, increases CAT activity, and upregulates transcription of antioxidant genes, including HO-1, which help maintain redox homeostasis 17

Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease

The intrinsic pathway is initiated by a change in mitochondrial membrane permeability, which not only activates caspase-9 and the downstream execution pathway via cytochrome C release, but also releases ROS