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Description

A novel drug combination of Mangiferin and Cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4/NFB/NLRP3 activation-induced Pyroptosis

Partanen T, Rissanen A

Metabolic activation of specific natural products from herbal and dietary supplements is mediated by hepatic cytochrome P450 or intestinal bacteria, and generates chemical reactive/toxic metabolites that bind to cellular reduced glutathione or macromolecules, and form reactive metabolites-glutathione/protein/DNA adducts, and these protein/DNA adducts can result in toxicities