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Serum Vitamin B12 levels and methylmalonic acid (MMA) tests help confirm the deficiency

Temporarily discontinuing self-initiated supplements whilst awaiting medical review is reasonable if symptoms are troublesome, particularly if you began supplementation without confirmed deficiency

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Cellular methylation and NAD pool dynamics the only well-characterized chemical probe that simultaneously raises tissue NAD and SAM, enabling clean studies of the methyl-donor / NAD-salvage interface [1,2]