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We cross-referenced coimmunoprecipitation and proximity labeling data sets, which accounted for three different NHR-49 strains including the overexpressed all-tissue NHR-49::GFP under fed and fasted conditions 42 and the endogenous N- and C-terminal TurboID tagged NHR-49 48

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Its essential for the upkeep of various organ systems, cellular metabolism, and brain functions, plays a critical role in energy metabolism, immune function, and nerve health

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Evidence boundary The published trial record describes safety more clearly than efficacy