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Uric acid triggers NOD-like receptor protein 3-dependent inflammation, with important implications for systemic inflammatory responses

Notably, Withaferin A treatment also increased the levels of mono-oxygenated (+1) PE and PC species, which may be products of lipids peroxidized via the lipid peroxidase activity of GPX4 16

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Interestingly, ORP8 expression levels were not strongly impacted during adipocyte differentiation, while ORP5 expression was highly variable

Wei, P., Han, G., & Wang, Y