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The concentration of the conjugate of the invention in the pharmaceutical composition can vary widely, i.e., from less than about 0.1% by weight, usually being at least about 1% by weight to as much as 20% by weight or more

1b), with higher DNA methylation levels for colon tumors than in matched normal tissue in the target regions, lower DNA methylation in the drug-treated leukemia cell lines, decreasing DNA methylation with decreasing concentrations of in vitro methylated DNA (titration 1) and cancer cell line DNA (titration 2), and similar DNA methylation levels for DNA extracted from fresh-frozen vs

The resultant increased levels of the chemokines and other proinflammatory reactions, are thought to contribute to tubule-interstitial disease (Qian et al., 2010), decreased renal perfusion and intra-tubular casts formed by the interaction of heme proteins with Tamm-Horsfall protein (Tracz et al., 2007)

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Weight fluctuates daily due to water retention, food volume, and hormonal cycles, so weekly averages provide better data than daily numbers