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MS affects over 2.5 million people worldwide, especially women and young, usually with an age of onset between 18 and 40 years, seriously reducing the life quality and causing a significant financial burden (Walton et al., 2020)

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Dutasteride (brand name Avodart) is a 5-alpha reductase inhibitor originally approved by the FDA for benign prostatic hyperplasia, an enlarged prostate condition

Surprisingly, the growth defect observed in the Z::metB KD under in-vivo conditions, while significant, was less pronounced than that observed in vitro

Alterations in the gut microbiome and cecal metabolome during klebsiella pneumoniae-induced pneumosepsis