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Phase 12 Trial of antisense oligonucleotide tofersen for SOD1 ALS

J.MaierN

The base of most IV formulations is normal saline (0.9% sodium chloride) or lactated Ringer's solution, both of which are isotonic fluids that effectively restore hydration at the cellular level

Spontaneous iron overload in Sprague-Dawley rats

These studies have found a significant reduction in white matter volume and alterations in the integrity of myelin that suggest deterioration during aging (Pakkenberg and Gundersen, 1997