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In 4.2 / mice, we confirmed that mitapivat improves iron homeostasis by both reduction in chronic hemolysis and in c-duodenal iron absorption

6 The histological spectrum of NAFLD ranges from simple steatosis with accumulation of triglycerides by hepatocytes to non-alcoholic steatohepatitis (NASH), characterized by apoptosis, necrosis, inflammatory cell infiltration, ballooning, and fibrosis against a steatotic background