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Description

Compound 102 exhibited overt suppression of ROS accumulation in a dose-dependent manner with an EC 50 of about 11.4 M (fluorescent intensity determined by ImageJ and a plate reader, Supplementary Figures S7 , S8 )

Herein we report on characterization of the acyl group- and site-selectivity of seven human sirtuins using acylated nucleosomes as substrates, by quantitative mass spectrometry-based analysis

This TPC value was 4.3 times higher than that obtained through Soxhlet extraction (42.03 mg GAE/g DE)

doi: 10.2337/dc11-2055 183 DeleskogALjungRForsellYNevrianaAAlmasAMllerJ

"Abstract PRO 2: LEE01 1 : an orally bioavailable, selective small molecule inhibitor of CDK4/6 reactivating Rb in cancer." Mot Cancer Ther 2013, 12, 1 1 S:PR02