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Always seek the advice of a physician or other qualified health provider with any questions regarding a medical condition.

The accumulation of amphetamines effectively reverses the transporter carrier mechanisms, leading to a massive, non-exocytotic efflux of vesicular dopamine out into the cytosol, where it is subsequently transported into the synaptic cleft (Wimalasena 2011)(see Figure 2 Mechanism B)

( Epub 2017 Jul 12 PMID: 28701075 ) Kale P, Addepalli V (2014) Augmentation of antidepressant effects of duloxetine and bupropion by caffeine in mice

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A GFD prevents these phenomena by curtailing shared sequences and cross-reactivity