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In addition to energy, erythrocytes require reducing power in the form of nicotinamide adenine dinucleotide phosphate (NADP) and NADPH to counteract the oxidative processes in their oxygen-rich environment

To identify the major cell types, we manually annotated 12 cell types based on specific marker genes within each cluster and the similarity matrix of the cell clusters (Fig

In this section, we review key findings from different surgical contexts: cardiac surgery (often involving global ischemia and extracorporeal circulation), neurosurgery (with focus on brain inflammation and cognitive outcomes), and abdominal surgeries involving liver and kidney ischemia (such as transplant or major resections)

Human studies have produced mixed results, but longer-term research suggests that ordinary oral glutathione can increase glutathione stores in some blood and tissue compartments