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Which classes of glutathione S-transferases in each cellular system is directly responsible for involvement of aflatoxin-GSH conjugate formation What is the relationship between the efficiency of glutathione conjugation system and toxic action of aflatoxins in different cell systems

Design The next design iteration is based on the prediction of enzyme ratio needed for the maximum titer of GSH

However, our literature searches showed that AFs interfere with DNA integrity, increase the secretion of pro-inflammatory factors, cytokines, and chemokines, inhibit DNA repair mechanisms, induce genomic instability, increase lipid peroxidation, induce DNA damage, cause tissue necrosis and organ failure, and dysregulate innate and adaptive immunity (290, 298300)

Taddei, Yale University, New Haven, CT, Michael Volk, Loma Linda University, Andrzej Kosinski, Duke Clinical Research Institute, Marie Bakitas, University of Alabama at Birmingham and Victor J

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