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Although cysteine can be derived from the catabolism of extracellular glutathione, protein catabolism or de novo synthesis from methionine, 12,13,14 the major source of cellular cysteine is the dietary intake of cystine, the oxidised form of cysteine

May 15 2018;44:45-55

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The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome

Introduction Gastric and gastroesophageal junction adenocarcinoma (GEA) remains a considerable health problem, ranking fourth as the leading cause of cancer-related death globally, with more than 700,000 deaths in 2020 ( Among the most successfully exploited targets in GEA is angiogenesis with the VEGFR2-directed antibody ramucirumab being the second targeted agent to be approved, either alone or combined with paclitaxel, for advanced GEA failing prior platinum and fluoropyrimidine chemotherapy ( The biological rationale for angiogenesis targeting in GEA Angiogenesis enables the generation of a neovasculature from pre-existing blood vessels sustaining tumor progression and invasion since the early stages of cancer development ( In recent years, lights have been shed on the molecular mechanisms underpinning VEGF/VEGFR-mediated angiogenesis, among which the hypoxia-inducible factor-1 (HIF-1) activation through the hypoxic neoplastic milieu is the best-established one